Which medications in the drug class Antidepressants, Other are used in the treatment of Chronic Pain Syndrome?

Updated: Jan 14, 2020
  • Author: Manish K Singh, MD; Chief Editor: Stephen Kishner, MD, MHA  more...
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Answer

Antidepressants, Other

These agents increase the synaptic concentration of serotonin and/or norepinephrine in the CNS by inhibiting their reuptake by the presynaptic neuronal membrane.

Amitriptyline

Amitriptyline is an analgesic for certain chronic and neuropathic pain.

Nortriptyline (Pamelor)

Nortriptyline has demonstrated effectiveness in the treatment of chronic pain. By inhibiting the reuptake of serotonin and/or norepinephrine by the presynaptic neuronal membrane, this drug increases the synaptic concentration of these neurotransmitters in the CNS. Pharmacodynamic effects such as the desensitization of adenyl cyclase and down-regulation of beta-adrenergic receptors and serotonin receptors also appear to play a role in its action.

Duloxetine (Cymbalta)

Duloxetine is indicated for diabetic peripheral neuropathic pain. It is a potent inhibitor of neuronal serotonin and norepinephrine reuptake.

Venlafaxine (Effexor, Effexor XR)

Venlafaxine inhibits neuronal serotonin and norepinephrine reuptake. In addition, it causes beta-receptor down-regulation. Venlafaxine may decrease neuropathic pain and help with sleep and other mood disorders (depression or depressive symptoms).

Fluoxetine (Prozac)

Fluoxetine is an atypical non ̶ tricyclic antidepressant (non-TCA) with potent specific 5HT-uptake inhibition and fewer anticholinergic and cardiovascular adverse effects than TCAs. Consider this drug as an alternative to TCAs.

Sertraline (Zoloft)

Sertraline is an atypical non-TCA with potent specific 5HT-uptake inhibition and fewer anticholinergic and cardiovascular adverse effects than TCAs. Consider it as an alternative to TCAs.

Paroxetine (Paxil, Pexeva)

Paroxetine is an atypical non-TCA with potent specific 5HT-uptake inhibition and fewer anticholinergic and cardiovascular adverse effects than TCAs. Consider it as an alternative to TCAs.


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