Which medications are used in the treatment of chronic pain syndrome (CPS)?

Updated: Jan 14, 2020
  • Author: Manish K Singh, MD; Chief Editor: Stephen Kishner, MD, MHA  more...
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Tizanidine may improve the inhibitory function in the central nervous system (CNS) and can provide pain relief. Amitriptyline (Elavil) and nortriptyline (Pamelor) are the tricyclic antidepressants (TCAs) most frequently used to treat chronic pain. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft), as well as the selective serotonin/norepinephrine reuptake inhibitor (SNRI) duloxetine (Cymbalta), are commonly prescribed by many physicians. Other antidepressants, such as doxepin, desipramine protriptyline, and buspirone, also can be used.

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