Which medications in the drug class Nonsteroidal anti-inflammatory drugs are used in the treatment of Mechanical Low Back Pain?

Updated: Mar 30, 2020
  • Author: Everett C Hills, MD, MS; Chief Editor: Stephen Kishner, MD, MHA  more...
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Nonsteroidal anti-inflammatory drugs

Have analgesic, anti-inflammatory, and antipyretic activities. [39] Mechanism of action is not known, but they may inhibit COX activity and prostaglandin synthesis. Other mechanisms may also exist, such as inhibition of leukotriene synthesis, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation, and various cell-membrane functions.

Aspirin (Anacin, Ascriptin)

Effective in most mechanical LBP cases. Irreversibly inhibits platelet function, leading to prolonged bleeding times.

Naprosyn (Naproxen, Naprelan, Naprosyn)

For relief of mild to moderate pain; inhibits inflammatory reactions and pain by decreasing activity of COX, which results in a decrease of prostaglandin synthesis.

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