Which medications in the drug class Muscle relaxants are used in the treatment of Mechanical Low Back Pain?

Updated: Mar 30, 2020
  • Author: Everett C Hills, MD, MS; Chief Editor: Stephen Kishner, MD, MHA  more...
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Muscle relaxants

Mechanism of action is not fully understood.

Cyclobenzaprine (Flexeril)

Skeletal muscle relaxant that acts centrally and reduces motor activity of tonic somatic origins, influencing alpha and gamma motor neurons.

Structurally related to TCAs and thus carries some of their same liabilities. Given in combination with an NSAID (similar to carisoprodol).

Orphenadrine (Norflex)

While exact mode of action not well understood, has shown clinical effectiveness in muscular injury. Effectiveness may be related to analgesic properties. May have atropinelike effects and analgesic properties.

Carisoprodol (Soma)

Short-acting medication that may have depressant effects at spinal cord level. Often given in combination with an NSAID.

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