Which medications in the drug class Analgesics, Other are used in the treatment of Coccyx Pain?

Updated: Jan 07, 2021
  • Author: Patrick M Foye, MD; Chief Editor: Consuelo T Lorenzo, MD  more...
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Answer

Analgesics, Other

Pain control is essential to quality patient care. Analgesics ensure patient comfort and have sedating properties that may be beneficial for patients who experience pain.

Acetaminophen (Aspirin Free Anacin, FeverAll, Tylenol, Mapap)

Acetaminophen is a first-line medication for treating pain in patients with documented hypersensitivity to aspirin or NSAIDs, with upper GI disease, or who are taking oral anticoagulants.

It is effective in relieving mild to moderate acute pain; however, acetaminophen has no peripheral anti-inflammatory effects. It may be preferred in elderly patients because of fewer GI and renal side effects.

Tramadol (Ultram, Ryzolt, Rybix ODT)

Tramadol inhibits ascending pain pathways, altering the patient's perception of and response to pain. It inhibits the reuptake of norepinephrine and serotonin.

Pregabalin (Lyrica)

Pregabalin is a structural derivative of gamma-aminobutyric acid (GABA); its mechanism of action is unknown. Pregabalin binds with high affinity to the alpha2-delta site (a calcium channel subunit). It reduces the calcium-dependent release of several neurotransmitters in vitro, possibly by modulating calcium channel function. Pregabalin has been approved by the US Food and Drug Administration (FDA) for the treatment of neuropathic pain associated with diabetic peripheral neuropathy or postherpetic neuralgia.

Fentanyl citrate (Duragesic, Abstral, Actiq, Fentora, Onsolis)

Fentanyl citrate is a synthetic opioid that has 75-200 times more potency and a much shorter half-life than morphine sulfate. It has fewer hypotensive effects than morphine and is safer in patients with hyperactive airway disease because of minimal or no associated histamine release. By itself, fentanyl citrate causes little cardiovascular compromise, although the addition of benzodiazepines or other sedatives may result in decreased cardiac output and blood pressure.

Fentanyl citrate is highly lipophilic and protein-bound. Prolonged exposure to it leads to accumulation of the drug in fat and delays the weaning process. Consider continuous infusion because of the medication's short half-life.

The parenteral form is the drug of choice for conscious-sedation analgesia. Fentanyl citrate is ideal for analgesic action of short duration during anesthesia and the immediate postoperative period. It is an excellent choice for pain management and sedation with short duration (30-60 min) and is easy to titrate. The drug's effects are easily and quickly reversed by naloxone.

After the initial parenteral dose of fentanyl citrate, subsequent parenteral doses should not be titrated more frequently than every 3 or 6 hours thereafter.

The transdermal form is used only for chronic pain conditions in opioid-tolerant patients. When using the transdermal dosage form, most patients are controlled with 72-hour dosing intervals; however, some patients require dosing intervals of 48 hours.

Oxycodone (OxyContin, Roxicodone)

Oxycodone is indicated for the relief of moderate to severe pain.

Oxycodone and acetaminophen (Percocet, Roxicet, Endocet, Primlev, Tylox)

This drug combination is indicated for the relief of moderate to severe pain.


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