Which medications in the drug class Antibiotics are used in the treatment of Prepatellar Bursitis?

Updated: Sep 15, 2020
  • Author: Divakara Kedlaya, MBBS; Chief Editor: Dean H Hommer, MD  more...
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Antibiotics should be started if septic prepatellar bursitis is suspected or documented after aspiration of bursal fluid for Gram stain and culture. An initial antibiotic can be selected based on a common pathogen (Staphylococcus aureus) and Gram stain results. In some cases of severe inflammation and in immunocompromised individuals, intravenous (IV) antibiotics may be required.

Patients with high risk for methicillin-resistant S aureus (MRSA) infection should receive empiric therapy with an antimicrobial agent that has activity against MRSA, such as IV vancomycin or daptomycin (in cases of severe inflammation) or oral clindamycin, doxycycline, or trimethoprim-sulfamethoxazole (in mild cases). [30]

In a retrospective study of 82 patients treated for severe septic bursitis (in most cases, prepatellar bursitis), Martinez-Taboada et al investigated the effectiveness of antibiotic therapy using cloxacillin, either alone or in combination with another antibiotic. [31] The authors concluded that if extensive cellulites are not present, cloxacillin may by itself be sufficient to treat severe septic bursitis. In particularly severe cases, however, they found that cloxacillin administered in combination with gentamicin appears to be a better treatment choice.

Cephalexin (Keflex, Biocef)

First-generation cephalosporin arrests bacterial growth by inhibiting bacterial cell wall synthesis. Bactericidal activity against rapidly growing organisms. Primary activity against skin flora; used for skin infections or prophylaxis in minor procedures.

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