What is the role of supplemental oxygen in the treatment of central sleep apnea (CSA)?

Updated: Aug 25, 2020
  • Author: Kendra Becker, MD, MPH; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Supplemental oxygen may be effective in some patients with CSB-CSA due to heart failure and has also been shown to improve ejection fraction. [36] It is thought to work by decreasing the hypoxic drive and thus attenuating the hyperventilatory response to a change in PaCO2. When comparing oxygen therapy to ASV, CSA-CSR is reduced to a greater extent by ASV than oxygen therapy over 8 weeks but oxygen therapy is better accepted. [37] Oxygen is effective against high-altitude periodic breathing and improves the sleep architecture. Any patient with central sleep apnea and significant hypoxemia is a potential candidate for a trial with supplemental oxygen. The optimal flow rate can be titrated during PSG until central sleep apnea resolves.

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