When is noninvasive bilevel positive-pressure ventilation (PPV) indicated in the treatment of chronic hypoventilation syndromes?

Updated: Jul 22, 2021
  • Author: Jazeela Fayyaz, DO; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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The indications for noninvasive bilevel PPV for nocturnal hypoventilation syndromes have been formulated based on the available literature. Patients considered for this therapy should have at least 1 of the following:

  • A disease known to cause hypoventilation

  • Symptoms and signs of hypoventilation present

  • Failure to respond to first-line therapies in mild cases of hypoventilation - ie, treatment of primary underlying disease with bronchodilators, respiratory stimulants, weight loss, supplemental oxygen, or continuous positive airway pressure (CPAP) [18]

  • Moderate to severe hypoventilation

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