What is the prognosis of hypoventilation syndrome?

Updated: Jul 22, 2021
  • Author: Jazeela Fayyaz, DO; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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The prognosis of patients with hypoventilation syndromes is variable, being dependent on the underlying cause of hypoventilation and the severity of the underlying illness.

The morbidity and mortality rates of patients with hypoventilation syndromes depend on the specific etiology of the hypoventilation. Pulmonary hypertension is more common and more severe in patients with OHS than in those with only obstructive sleep apnea (OSA).

OHS patients have higher rates of ICU admission compared with patients with similar levels of obesity without hypoventilation. [2]

The morbidity and mortality rates of each of the above-mentioned disorders are increased secondary to the presence of respiratory failure and alveolar hypoventilation.

Some of the consequences of hypoventilation, such as cor pulmonale and pulmonary hypertension, may be irreversible.

Studies reported several decades ago showed significant increase in mortality in patients with OHS. This increased mortality is likely secondary to an increased risk of arrhythmias and cardiovascular complications.

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