What is obesity-hypoventilation syndrome?

Updated: Jul 22, 2021
  • Author: Jazeela Fayyaz, DO; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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OHS is another well-known cause of hypoventilation. Abnormal central ventilatory drive and obesity contribute to the development of OHS. OHS is defined as a combination of obesity and a body mass index greater than or equal to 30kg/m2 with awake chronic hypercapnia (PaCO2 >45 mm Hg). Other disorders that may cause hypoventilation should be ruled out first. Approximately 90% of patients with OHS also have obstructive sleep apnea (OSA). [2] Hypoventilation is worse during rapid eye movement (REM) sleep than during non-REM sleep.

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