What are contraindications for methacholine challenge testing?

Updated: May 14, 2020
  • Author: Kevin McCarthy, RPFT; Chief Editor: Nader Kamangar, MD, FACP, FCCP, FCCM  more...
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Absolute contraindications include FEV1 less than 1.5 L in adults, less than 1 L in children, recent severe acute asthma, myocardial infarction or cerebral vascular accident within 3 months, and arterial aneurysm.

Relative contraindications include moderate baseline airway obstruction, spirometry-induced bronchoconstriction, recent upper respiratory tract infection (URI), exacerbation of asthma, hypertension, pregnancy, and epilepsy.

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