Which medications in the drug class Soluble Guanylate Cyclase (sGC) Stimulators are used in the treatment of Pulmonary Arterial Hypertension?

Updated: Apr 25, 2018
  • Author: Kristin E Schwab, MD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Soluble Guanylate Cyclase (sGC) Stimulators

Soluble guanylate cyclase (sGC) is an enzyme in the cardiopulmonary system and the receptor for nitric oxide. PAH is associated with endothelial dysfunction, impaired synthesis of nitric oxide, and insufficient stimulation of the nitric oxide-sGC-cGMP pathway.

Riociguat (Adempas)

Riociguat elicits a dual mode of action. It sensitizes sGC to endogenous nitric oxide by stabilizing the nitric oxide-sGC binding, and it directly stimulates sGC via a different binding site, independently of nitric oxide. It is indicated for chronic thromboembolic pulmonary hypertension and PAH.

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