What is the role of soluble guanylate cyclase (sGC) for the treatment of pulmonary arterial hypertension (PAH)?

Updated: Apr 25, 2018
  • Author: Kristin E Schwab, MD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Soluble guanylate cyclase (sGC) is an enzyme in the cardiopulmonary system and the receptor for nitric oxide. PAH is associated with endothelial dysfunction, impaired synthesis of nitric oxide, and insufficient stimulation of the nitric oxide-sGC-cGMP pathway.


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