What is the role of surgery in the treatment of diffuse parenchymal lung diseases (DPLDs)?

Updated: Sep 15, 2020
  • Author: Eleanor M Summerhill, MD, FACP, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Surgery in the form of either thoracoscopic (preferred) or open lung biopsy is often indicated to obtain tissue specimens for definitive diagnosis.

More recently, lung transplantation has become a treatment option for selected patients with advanced disease refractory to medical therapy. [20] It is the only interventional modality that has been shown to increase survival time in patients with UIP/IPF. [21, 22] Survival rates worldwide after single lung transplantation are approximately 74% at 1 year, 58% at 3 years, 47% at 5 years, and 24% at 10 years. Survival rates are lower for bilateral lung transplantation. Following transplantation, patients overall report improved quality of life with better physical, social, and general health functioning.

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