How does the presence of hyponatremia affect the prognosis of acute pulmonary embolism (PE)?

Updated: Sep 18, 2020
  • Author: Daniel R Ouellette, MD, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Elevated levels of brain-type natriuretic peptides (BNP) may also provide prognostic information. [57] A meta-analysis demonstrated a significant association between elevated N-terminal–pro-BNP (NT-pro-BNP) and right ventricular function in patients with pulmonary embolism (P< .001), leading to an increased risk for complicated in-hospital course (odds ratio [OR] 6.8; 95% confidence interval [CI], 9.0-13) and 30-day mortality (OR 7.6; 95% CI, 3.4-17). [62] Importantly, increased NT-pro-BNP alone does not justify more invasive treatment.

A recent study by Scherz et al analyzed a large sample of patients hospitalized with acute pulmonary embolism. Hyponatremia at presentation was common and was associated with a higher risk of 30-day mortality and readmission. [63]

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