What should be considered in the workup of patients with suspected pulmonary embolism (PE)?

Updated: Sep 18, 2020
  • Author: Daniel R Ouellette, MD, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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A hypercoagulation workup should be performed if no obvious cause for embolic disease is apparent. This may include screening for conditions such as the following:

  • Antithrombin III deficiency

  • Protein C or protein S deficiency

  • Lupus anticoagulant

  • Homocystinuria

  • Occult neoplasm

  • Connective tissue disorders

More clinical studies are needed to evaluate the utility of new approaches to the condition’s diagnosis. The availability of diagnostic tests, as well as cost-effectiveness analysis, local traditions, and the expertise of radiologists involved in the diagnosis, are considerations in the workup of a patient in whom pulmonary embolism is suspected.

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