Which medications are used for the treatment of adenovirus pneumonia?

Updated: Mar 24, 2021
  • Author: Zab Mosenifar, MD, FACP, FCCP; Chief Editor: John J Oppenheimer, MD  more...
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Answer

Cidofovir has demonstrated good in vitro activity against adenoviruses, including serotype 14. Cidofovir has shown some efficacy in treating adenovirus infection in immunocompromised patients, especially HSCT recipients. [89] The dose is 5 mg/kg/wk for two weeks, then every two weeks plus probenecid 1.25 g/m2 given three hours before cidofovir and three and nine hours after each infusion. Alternate dosing is 1 mg/kg IV three times a week.

The in vitro activity of ribavirin against adenovirus, however, has been variable. For example, in one study, species C was susceptible to ribavirin, while other species were more variable. [90] Some anecdotal reports exist regarding improvement in some patients with HSCT and leukemia, although other studies have not shown any efficacy. Thus, routine use of ribavirin is not recommended. [91, 92, 93]


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