Which virus-specific lab studies are used for the diagnosis of hantavirus-caused pneumonia?

Updated: Mar 24, 2021
  • Author: Zab Mosenifar, MD, FACP, FCCP; Chief Editor: John J Oppenheimer, MD  more...
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Answer

Hantavirus infection is based on serum detection of hantavirus–specific antibody and, for the majority of the United States, on the development of Sin Nombre Virus (SNV) specific antibodies. Less commonly, in a more research-oriented setting, reverse transcriptase polymerase chain reaction (RT-PCR) can be used to detect hantavirus RNA in peripheral blood mononuclear cells, lung tissue, and/or red blood cells. The serodiagnosis of acute hantavirus infection is confirmed by detecting the genetic material in peripheral blood mononuclear cell preparations with RT-PCR.


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