Which virus-specific lab studies are used for the diagnosis of adenoviruses pneumonia?

Updated: Mar 24, 2021
  • Author: Zab Mosenifar, MD, FACP, FCCP; Chief Editor: John J Oppenheimer, MD  more...
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Answer

Adenoviruses can be isolated from respiratory secretions and can be grown in human embryonic kidney cells, human laryngeal tumor cells (HEp-2), and HeLa cells. Cytopathic effects appear in 2-20 days and include eosinophilic and diffuse basophilic intranuclear inclusions.

Serotype 14 can be diagnosed by viral culture, direct fluorescent antibody rapid antigen detection, and PCR. In the HSCT population, adenovirus PCR from plasma has been shown to be a good predictor of disease, especially at a threshold of 1000 copies/mL. [70]

If adenovirus 14 is suspected, because of severity of illness and negative bacterial and viral cultures, clinicians should contact their state public health department for aid in testing. [71]


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