What are the clinical manifestations of human metapneumovirus (HMPV) pneumonia?

Updated: Mar 24, 2021
  • Author: Zab Mosenifar, MD, FACP, FCCP; Chief Editor: John J Oppenheimer, MD  more...
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Symptoms of human metapneumovirus (hMPV) infection are similar to those caused by other viruses: nasal congestion and cough are present in 82-100% of cases. Other symptoms include rhinorrhea (69-82%), dyspnea (69%), wheezing (62%), sputum production (55%), hoarseness (46-91%), and sore throat (23-45%). The incubation period is 5-6 days.

In one study, hoarseness was more common in hMPV than in RSV infection. Hoarseness, dyspnea, and wheezing were significantly more common among the elderly older than 65 years than among adults younger than 40 years. [22]

In different studies, cough was reported in 90% of patients; dyspnea, in 83%; coryza, in 88%; and fever, in 52-92%. Among the physical signs, rales, wheezing, or stridor were found in one half of infected children. In children, hMPV is an important cause of wheezing (9% in a 132 case series). Fever, cough, dyspnea, and sore throat are commonly described in adults. In HSCT recipients, hMPV pneumonia is reported and tends to cause respiratory failure.

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