Which body sites are affected by disseminated fungal infections?

Updated: Jun 21, 2019
  • Author: Romeo A Mandanas, MD, FACP; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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Answer

Answer

Fungi may simply colonize body sites with no apparent disease, or they may invade, producing a wide variety of syndromes. The development of disease is a result of the susceptibility of the host and the virulence of the pathogen. [1]

Endemic mycoses with associated dissemination can affect skin (eg, papules, pustules, plaques, ulcers, abscesses, proliferative lesions that may mimic skin cancer as in B dermatitidis infection), bone and joints, and the brain and meninges (meningitis with poor prognosis [10-20%], brain abscess in infection with Aspergillus and Mucor species).

Other affected sites include the following:

  • Kidneys

  • Liver and spleen (hepatosplenic candidiasis)

  • Muscle (Candida species)

  • Eye (endophthalmitis; in Candida species infection)

  • Nasal passages and sinuses (Aspergillus and Mucor species)

  • Bloodstream and bone marrow (septicemia or sepsis syndrome)


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