When are macrolides indicated for the treatment of bacterial pneumonia?

Updated: Sep 30, 2020
  • Author: Justina Gamache, MD; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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Macrolides are primarily recommended for the treatment of CAP in patients younger than 60 years of age who are nonsmokers without a comorbid illness. Give special consideration to recommendations for antibiotic use in patients with comorbid illnesses or those with CAP who are older than 60 years of age. Although patients in this group are still susceptible to S pneumoniae, they should receive treatment for broader coverage that includes Haemophilus, Moraxella, and other gram-negative organisms. Therefore, a prudent course of action for empiric outpatient therapy is to include: (1) one of the macrolide agents described previously plus a second- or third-generation cephalosporin or amoxicillin and clavulanate or (2) trimethoprim and sulfamethoxazole (TMP-SMZ) as a single agent.

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