When is clinical response to antibiotic therapy evaluated and adjusted in bacterial pneumonia?

Updated: Sep 30, 2020
  • Author: Justina Gamache, MD; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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Clinical response to antibiotic therapy should be evaluated within 48-72 hours of initiation. With appropriate antibiotic therapy, improvement in the clinical manifestations of pneumonia should be observed in 48-72 hours. Because of the time required for antibiotics to act, antibiotics should not be changed within the first 72 hours unless marked clinical deterioration occurs or the causative micro-organism is identified with some certainty. With pneumococcal pneumonia, the cough usually resolves within eight days and crackles heard on auscultation clear within three weeks.

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