Which medications in the drug class Tetracyclines are used in the treatment of Bacterial Pneumonia?

Updated: Sep 30, 2020
  • Author: Justina Gamache, MD; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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Answer

Tetracyclines

Doxycycline (Bio-Tab, Doryx, Doxy, Periostat, Vibramycin, Vibra-Tabs)

Doxycycline is an alternative agent for patients who cannot tolerate macrolides or penicillins. This agent is a broad-spectrum, synthetically derived bacteriostatic antibiotic in the tetracycline class. Doxycycline is almost completely absorbed, concentrates in the bile, and is excreted in urine and feces as a biologically active metabolite in high concentrations.

Doxycycline inhibits protein synthesis and, thus, bacterial growth, by binding to the 30S and possibly 50S ribosomal subunits of susceptible bacteria. It may block dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest.

Omadacycline (Nuzyra)

Omadacycline is an aminomethylcycline antibacterial within the tetracycline drug class that binds to the 30S ribosomal subunit and blocks protein synthesis. It is active in vitro against gram-positive bacteria expressing tetracycline resistance active efflux pumps (tetK and tet L) and ribosomal protection proteins (tet M). It is indicated for the treatment of community-acquired bacterial pneumonia (CABP) in adults caused by susceptible microorganisms, including Streptococcus pneumoniae, Staphylococcus aureus (methicillin-susceptible isolates), Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae. Omadacycline is available for intravenous or oral administration.


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