Which medications in the drug class Penicillins, Extended-Spectrum are used in the treatment of Bacterial Pneumonia?

Updated: Sep 30, 2020
  • Author: Justina Gamache, MD; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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Answer

Penicillins, Extended-Spectrum

Piperacillin and tazobactam sodium (Zosyn)

The piperacillin and tazobactam sodium combination is an antipseudomonal penicillin plus beta-lactamase inhibitor. This agent inhibits biosynthesis of cell wall mucopeptide and is effective during stage of active multiplication.

Perform CBC counts before the initiation of therapy and at least weekly during therapy. In addition, monitor for liver function abnormalities by measuring AST and ALT levels during therapy, and perform urinalysis and BUN and creatinine determinations during therapy. Adjust the dose if laboratory values become elevated, and monitor blood levels to avoid possible neurotoxic reactions.

Ticarcillin and clavulanate (Timentin)

It inhibits biosynthesis of the cell wall mucopeptide and is effective during the stage of active growth.

It is an antipseudomonal penicillin plus a beta-lactamase inhibitor that provides coverage against most gram-positive, most gram-negative, and most anaerobic bacteria


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