What are the effects of interactions between viruses and bacteria in bacterial pneumonia?

Updated: Sep 30, 2020
  • Author: Justina Gamache, MD; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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The classic explanation behind the viral-bacterial interplay focuses on the disruption of the respiratory epithelium by the virus, providing an opportinistic environment for bacterial infection. However, evidence depicts much more complex and possibly synergistic interactions between viruses and bacteria, including alteration of pulmonary physiology, downregulation of the host immune defense, changes in expression of receptors to which bacteria adhere, and enhancement of the inflammatory process. [21]

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