Are alteplase and deoxyribonuclease (DNase) effective treatments for pleural effusion (fluid on the lungs)?

Updated: Dec 28, 2018
  • Author: Kamran Boka, MD, MS; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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Answer

A randomized trial of 210 participants with pleural infection documented that instillation of alteplase and DNase produced significantly greater drainage of pleural effusion, less need for surgical referral or surgical intervention, shorter hospital stays, and a decrease in pleural fluid inflammatory markers compared with placebo. [49]


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