How are pleural fluid levels of adenosine deaminase (ADA) and interferon-gamma used in the diagnosis of tuberculous pleuritis?

Updated: Dec 28, 2018
  • Author: Kamran Boka, MD, MS; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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Answer

Adenosine deaminase (ADA) activity of greater than 43 U/mL in pleural fluid supports the diagnosis of tuberculous pleuritis. However, the test has a sensitivity of only 78%. Therefore, pleural ADA values of less than 43-50 U/mL do not exclude the diagnosis of TB pleuritis. [34]

Interferon-gamma concentrations of greater than 140 pg/mL in pleural fluid also support the diagnosis of tuberculous pleuritis. Unfortunately, this test is not routinely available.


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