How much pleural fluid is recommended for cytology testing in the workup for pleural effusion (fluid on the lungs)?

Updated: Dec 28, 2018
  • Author: Kamran Boka, MD, MS; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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The sensitivity of cytology is not highly related to the volume of pleural fluid tested. Sending more than 50-60 mL of pleural fluid for cytology does not increase the yield of direct cytospin analysis, [32, 33] and volumes of approximately 150 mL are sufficient when both cytospin and cell block preparations are analyzed. [33]

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