Can pleural fluid levels of N-terminal pro-brain natriuretic peptide (NT-proBP) be used as a marker for heart failure–related pleural effusions?

Updated: Dec 28, 2018
  • Author: Kamran Boka, MD, MS; Chief Editor: Guy W Soo Hoo, MD, MPH  more...
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In addition, studies suggest that pleural fluid levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are elevated in effusions due to congestive heart failure. [28, 25] Moreover, elevated pleural NT-proBNP was demonstrated to out-perform pleural fluid BNP as a marker of heart failure–related effusion. [29] Thus, at institutions where this test is available, high pleural levels of NT-proBNP (defined in different studies as >1300-4000 ng/L) may help to confirm heart failure as the cause of an otherwise idiopathic chronic effusion.


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