What is the role of pulmonary function testing in the diagnosis of eosinophilic granuloma (histiocytosis X)?

Updated: Mar 29, 2018
  • Author: Eleanor M Summerhill, MD, FACP, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Pulmonary function testing in pulmonary Langerhans cell histiocytosis X (PLCH) patients can demonstrate all patterns of abnormality: Normal, restrictive, obstructive, or mixed. Most patients have normal or near-normal total lung capacity with near-normal spirometry findings. Gas exchange, as measured by the diffusing capacity for carbon monoxide, is generally reduced. In rare cases, patients have reversible airflow limitation.


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