What are the possible complications of eosinophilic granuloma (histiocytosis X)?

Updated: Mar 29, 2018
  • Author: Eleanor M Summerhill, MD, FACP, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
  • Print

Spontaneous pneumothorax is a common complication (10-20%) in pulmonary Langerhans cell histiocytosis X (PLCH).

PLCH is associated with an increased risk of malignancy, including Hodgkin and non-Hodgkin lymphoma, myeloproliferative disorders, and bronchogenic carcinoma. [10]

Pathologic fracture may occur at the site of bone lesions.

Diabetes insipidus occurs in 10-15% of patients and indicates disease in the central nervous system.

Pulmonary arterial hypertension and, rarely, cor pulmonale, may develop as a result of hypoxemia and/or vascular occlusion due to PLCH lesions.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!