What are the possible complications of eosinophilic granuloma (histiocytosis X)?

Updated: Mar 29, 2018
  • Author: Eleanor M Summerhill, MD, FACP, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Spontaneous pneumothorax is a common complication (10-20%) in pulmonary Langerhans cell histiocytosis X (PLCH).

PLCH is associated with an increased risk of malignancy, including Hodgkin and non-Hodgkin lymphoma, myeloproliferative disorders, and bronchogenic carcinoma. [10]

Pathologic fracture may occur at the site of bone lesions.

Diabetes insipidus occurs in 10-15% of patients and indicates disease in the central nervous system.

Pulmonary arterial hypertension and, rarely, cor pulmonale, may develop as a result of hypoxemia and/or vascular occlusion due to PLCH lesions.


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