What are the signs and symptoms of eosinophilic granuloma (histiocytosis X)?

Updated: Mar 29, 2018
  • Author: Eleanor M Summerhill, MD, FACP, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Presentations of pulmonary Langerhans cell histiocytosis X (PLCH) are variable. [9] Approximately 25% of patients are asymptomatic, and their disease is diagnosed after an evaluation of incidental findings on chest radiographs. Others present with respiratory or constitutional symptoms. In order of decreasing frequency, common presenting symptoms are as follows:

  • Nonproductive cough (56-70%)

  • Dyspnea (40%)

  • Fatigue (30%)

  • Weight loss (20-30%)

  • Chest pain (21%)

  • Spontaneous pneumothorax, which may be recurrent, is a classic presentation found in 10-20% of patients.

  • Fever (15%)

  • Cystic bone lesions (4-20%): These may be painful and may predispose the patient to pathologic fracture.


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