What is the role of anti-inflammatory therapy for bronchiectasis?

Updated: Jul 23, 2019
  • Author: Ethan E Emmons, MD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

The rationale of anti-inflammatory therapy is to modify the inflammatory response caused by the microorganisms associated with bronchiectasis and subsequently reduce the amount of tissue damage. Inhaled corticosteroids, [113] oral corticosteroids, [114] leukotriene inhibitors, [115] and nonsteroidal anti-inflammatory agents [115] have all been examined.

Although some evidence suggests a benefit from the use of these agents, some evidence does not, and findings are not universally definitive. [116] One study reported that inhaled corticosteroids are beneficial compared with placebo in patients with bronchiectasis, particularly those with associated P aeruginosa infections. [117]


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