What is the most common pulmonary function tests (PFTs) finding in bronchiectasis by?

Updated: Jul 23, 2019
  • Author: Ethan E Emmons, MD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

The most common abnormality is an obstructive airway defect, which may even be found in patients without a prior smoking history. In addition, patients with bronchiectasis have higher rates of yearly decline in forced expiratory volume in 1 second (FEV1) than patients without bronchiectasis. [69, 85] In patients with non-CF bronchiectasis, risk factors for a more rapid decline in FEV1 include colonization with Pseudomonas aeruginosa and higher concentrations of proinflammatory markers. [86]

Obstruction in bronchiectasis is not usually reversible with bronchodilator therapy. However, a subgroup of patients may develop hyperreactive airways in conjunction with their bronchiectasis that will respond to bronchodilators.

Restriction may be observed in patients with severe advanced disease secondary to scarring and atelectasis, but this is not common. Traction bronchiectasis most often occurs in the setting of a restrictive lung defect from underlying fibrosis.


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