Which medications in the drug class Mucolytic agents are used in the treatment of Atelectasis?

Updated: Oct 22, 2020
  • Author: Tarun Madappa, MD, MPH; Chief Editor: Nader Kamangar, MD, FACP, FCCP, FCCM  more...
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Mucolytic agents

N -acetylcysteine is only recommended for direct instillation via fiberoptic bronchoscopy or in an intubated patient. Therapy with mucolytics may promote sputum removal of thick mucous plugs and, therefore, helps treat atelectasis in many patients. Inhaled recombinant human deoxyribonuclease is a mucolytic agent successfully used in patients with cystic fibrosis.

N-acetylcysteine (Mucomyst)

N-acetylcysteine inhalations may be tried to encourage sputum expectoration in patients with tenacious sputum and mucous plugging.

Dornase alfa (Pulmozyme)

Dornase alfa cleaves and depolymerizes extracellular DNA and separates DNA from proteins. This allows endogenous proteolytic enzymes to break down the proteins; thus, decreasing viscoelasticity and surface tension of purulent sputum.

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