What is the relationship between middle lobe syndrome (recurrent atelectasis) and primary Sjögren syndrome?

Updated: Oct 22, 2020
  • Author: Tarun Madappa, MD, MPH; Chief Editor: Nader Kamangar, MD, FACP, FCCP, FCCM  more...
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Answer

Middle lobe syndrome has been reported as a pulmonary manifestation of primary Sjögren syndrome. Transbronchial biopsies performed in such patients revealed lymphocytic bronchiolitis in the atelectatic lobes. Atelectasis responds well to glucocorticoid treatment, suggesting that the peribronchiolar lymphocytic infiltrates may play an important role in the development of middle lobe syndrome in these patients. [4]


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