Which medications in the drug class Corticosteroid, Inhalant are used in the treatment of Asthma?

Updated: Jan 07, 2019
  • Author: Michael J Morris, MD, FACP, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Corticosteroid, Inhalant

Inhaled steroids include ciclesonide (Alvesco), beclomethasone (QVAR), triamcinolone, flunisolide (Nasalide), fluticasone (Flovent Diskus, Flovent HFA), budesonide (Pulmicort Flexhaler or Respules), and mometasone furoate inhalation powder (Asmanex Twisthaler). Steroids are the most potent anti-inflammatory agents. Inhaled forms are topically active, poorly absorbed, and least likely to cause adverse effects.

Ciclesonide (Alvesco)

Ciclesonide is an aerosol inhaled corticosteroid indicated for maintenance treatment of asthma as prophylactic therapy in adult and adolescent patients aged 12 years and older. It is not indicated for relief of acute bronchospasm. Corticosteroids have a wide range of effects on multiple cell types (eg, mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (eg, histamines, eicosanoids, leukotrienes, cytokines) involved in inflammation.

Beclomethasone (QVAR Redihaler)

This agent inhibits bronchoconstriction mechanisms; causes direct smooth muscle relaxation; and may decrease the number and activity of inflammatory cells, which, in turn, decreases airway hyperresponsiveness. It is available as a 40- or 80-mcg/actuation.

Fluticasone inhaled

Fluticasone has extremely potent vasoconstrictive and anti-inflammatory activity. It has a weak HPA-axis inhibitory potency when applied topically. It is available as a metered-dose inhaler aerosolized product (HFA) or DPI (Diskus).

Budesonide inhaled (Pulmicort Flexhaler or Respules)

Fluticasone has extremely potent vasoconstrictive and anti-inflammatory activity. It has a weak HPA-axis inhibitory potency when applied topically. It is available as a DPI in 90-mcg/actuation (delivers about 80 mcg/actuation) or 180-mcg/actuation (delivers about 160 mcg/actuation). A nebulized suspension (ie, Respules) is also available for young children.

Mometasone (Asmanex Twisthaler)

Mometasone is a corticosteroid for oral inhalation. It is indicated for asthma as prophylactic therapy.

Triamcinolone inhaled (Azmacort)

Triamcinolone alters the level of inflammation in airways by inhibiting multiple types of inflammatory cells and decreasing the production of cytokines and other mediators involved in the asthmatic response.


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