What are the benefits of omalizumab therapy in the treatment of asthma?

Updated: Jan 07, 2019
  • Author: Michael J Morris, MD, FACP, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

A study by Busse et al found that omalizumab further improved asthma control, nearly eliminated seasonal exacerbation peaks, and reduced the need for other medications to control asthma when added to a regimen of guidelines-based therapy in inner-city children, adolescents, and young adults. [82]

A study by Hanania et al found that omalizumab provided additional benefit in patients with severe allergic asthma that is insufficiently controlled with inhaled corticosteroids and long-acting beta2-agonists. [83] However, the results of the study were limited by early patient discontinuation (20.8%) and were limited because the study was not powered to detect rare safety events or treatment effect in the corticosteroid group.


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