What is the role of mannitol in the assessment of patients with symptoms of asthma?

Updated: Jan 07, 2019
  • Author: Michael J Morris, MD, FACP, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Mannitol is a provocation test that uses indirect stimuli, causing smooth muscle contraction by release of endogenous mediators, including prostaglandins, leukotrienes, and histamine. Mannitol is equivalent for the diagnosis of asthma compared with methacholine but is not currently available for use in the United States. [65]


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