What is the role of periostin measurement in the management of asthma?

Updated: Jan 07, 2019
  • Author: Michael J Morris, MD, FACP, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Periostin is a novel biomarker that is currently under investigation as a diagnostic and treatment adjunct. [59] Evidence suggests that periostin is a marker of Th2/eosinophilic inflammation and airway remodeling that occurs with asthma. While there are no therapies currently approved based on periostin testing, several investigational medications are being studied with periostin as a predictor of medication effect. In one phase IIb study, periostin was a good predictor of response to lebrikizumab in patients not controlled on inhaled corticosteroids, with an increase in FEV1 of 8.2% for high periostin levels compared with placebo with an increase in FEV1 of 1.6% for low periostin levels. Currently, there is no clinical role for routine periostin testing.


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