Which medications in the drug class Respiratory enzymes are used in the treatment of Alpha1-Antitrypsin (AAT) Deficiency?

Updated: Sep 11, 2020
  • Author: Dora E Izaguirre Anariba, MD, MPH; Chief Editor: John J Oppenheimer, MD  more...
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Respiratory enzymes

These drugs are used for long-term replacement in individuals with clinically demonstrable panacinar emphysema.

Alpha1-proteinase inhibitor (Prolastin-C, Aralast NP, Glassia, Zemara)

This is a sterile, stable, lyophilized preparation of purified human alpha1-antiprotease inhibitor prepared from pooled human plasma by using a cold alcohol fractionation process followed by further purification steps. Each unit of plasma is tested for HIV, hepatitis B, and hepatitis C before inclusion in the product. The product is treated with a solvent detergent mixture to inactivate viral agents to reduce the potential risk of infectious-agent transmission. No cases of viral infections have been attributed to the product. It is indicated as replacement (or augmentation) for normal serum alpha1-antiprotease to prevent progression of emphysema in patients with congenital deficiency of AAT with clinically evident emphysema.

These drugs have been approved for use in the United States.

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