What are the general management recommendations on obstructive lung disease in alpha1-antitrypsin deficiency (AATD)?

Updated: Sep 11, 2020
  • Author: Dora E Izaguirre Anariba, MD, MPH; Chief Editor: John J Oppenheimer, MD  more...
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Answer

General management of obstructive lung disease are as follows:

  • AAT repletion
  • Inhaled bronchodilators
  • Vaccinations against influenza and Pneumococcus to prevent infections
  • Supplemental oxygen when indicated by conventional criteria
  • Pulmonary rehabilitation for individuals with functional impairment
  • Consideration of lung transplantation for selected individuals with severe functional impairment and airflow obstruction
  • During acute exacerbations of COPD, AAT repletion should be included

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