How is alpha1-antitrypsin deficiency (AATD) staged?

Updated: Sep 11, 2020
  • Author: Dora E Izaguirre Anariba, MD, MPH; Chief Editor: John J Oppenheimer, MD  more...
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No specific grading system exists for alpha1-antitrypsin deficiency (AATD), but the severity of the emphysema that it creates can be staged using the body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index. [18] This 4-step evaluation of patients with chronic obstructive lung disease appears to identify a population with limited survival who might benefit from intensified therapy. The index has not been evaluated in a population of individuals with AATD.

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