Which medications in the drug class Antiplatelet agents are used in the treatment of Vascular Dementia?

Updated: Mar 26, 2018
  • Author: Kannayiram Alagiakrishnan, MD, MBBS, MPH, MHA; Chief Editor: Glen L Xiong, MD  more...
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Answer

Antiplatelet agents

Studies have shown antiplatelet agents are useful for preventing recurrent stroke. In vascular dementia, a pilot study showed that aspirin has positive effects on cognitive deficits. Recent studies have shown it may have some neuroprotective effects. Other antiplatelet agents are ticlopidine and clopidogrel.

Aspirin (Anacin, Ascriptin, Bayer aspirin)

Prevents platelet-aggregating thromboxane A2 by blocking prostaglandin synthetase action and thereby preventing prostaglandin synthesis.

Ticlopidine (Ticlid)

Used in patients who cannot tolerate aspirin therapy or in whom aspirin therapy fails.

Clopidogrel bisulfate (Plavix)

Antiplatelet drug that acts by direct inhibition of ADP binding to the platelet receptor and of subsequent ADP-mediated activation of the glycoprotein IIb/IIIa complex.


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