Which medications in the drug class Thyroid Products are used in the treatment of Dysthymic Disorder?

Updated: Oct 01, 2019
  • Author: Jerry L Halverson, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

Thyroid Products

These drugs are administered as an augmentation strategy. They may convert nonresponders (to antidepressants) to responders by increasing receptor sensitivity and enhancing the effects of antidepressants, particularly tricyclic antidepressants.

T3, liothyronine (Cytomel, Triostat)

Liothyronine is a synthetic form of natural thyroid hormone T3 converted from T4. Its duration of activity is short and allows for quick dosage adjustments in the event of overdosage. Liothyronine may need to be administered as often as 4 times daily. In its active form, the drug influences the growth and maturation of tissues.

The dose should be one quarter of the T4 dose, according to some; others recommend administering liothyronine alone.

T3/T4 combinations (Armour Thyroid, Westhroid, Nature-Throid)

These are mixtures of 1 part T3 to 4 parts T4; they carry the same advice and warnings that the 2 hormones do when administered separately. For desiccated thyroid, 1 grain (60 mg) contains 38 mcg T4 and 9 mcg T3. Thyrolar 1 contains 50 mcg T4 and 12.5 mcg T3.


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