Is injectable or oral administration of antipsychotic agents more effective for schizophrenia?

Updated: Mar 16, 2018
  • Author: Frances R Frankenburg, MD; Chief Editor: Glen L Xiong, MD  more...
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Answer

According to the results of a year-long randomized controlled trial, starting a long-acting injectable (LAI) antipsychotic after a first episode of schizophrenia is more effective than starting an oral antipsychotic. The study included 86 patients with a recent first episode of schizophrenia who were randomly assigned to receive LAI risperidone (n = 43) or oral risperidone (n = 43) for 12 months. Study data showed that the LAI formulation of risperidone proved superior to oral risperidone on measures of relapse and symptom control. The psychotic exacerbation and/or relapse rate was 5% in the LAI risperidone group vs 33% in the oral risperidone group. Treatment with LAI risperidone also provided better control of hallucinations and delusions. [85]


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