Which drugs are associated with mental status changes?

Updated: Mar 16, 2018
  • Author: Frances R Frankenburg, MD; Chief Editor: Glen L Xiong, MD  more...
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Many medications have been associated with mental status changes, especially the following:

  • Corticosteroids (psychosis, depression, or mania)

  • Levodopa (hallucinations or insomnia)

  • Antidepressants (mania)

  • Interferon alfa (depression)

  • Beta blockers, including those in eye drops (depression)

Substance abuse (eg, abuse of alcohol, cocaine, opiates, psychostimulants, or hallucinogens) not uncommonly leads to disturbed perceptions, thought, mood, and behavior. The anabolic steroids used by body builders and athletes can lead to psychotic symptoms. [75] Anticholinergic medications can lead to delirium, especially if abused.

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