Is there evidence of a common genetic variation that causes schizophrenia?

Updated: Mar 16, 2018
  • Author: Frances R Frankenburg, MD; Chief Editor: Glen L Xiong, MD  more...
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Answer

A recent genome-wide association study beginning with a Swedish sample of 5,000 cases and 6,000 controls compared the results with a previous genome-wide association study and findings of single-nucleotide polymorphisms (SNP) in independent examples. It found a clustering at 22 loci, 14 of which were new. Most of the SNPs were common and, collectively, could account for perhaps as much as one third of the variance in liability for schizophrenia. In other words, common genetic variation may be involved in schizophrenia. This is somewhat similar to the understanding of other complex trait diseases such as coronary artery disease. [44]

Schizophrenia and bipolar disorder are likely to have a large overlap in genetic risk factors, but only a small portion of this genetic risk has been identified. [45]


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