What is the role of the GRM3 gene in schizophrenia?

Updated: Mar 16, 2018
  • Author: Frances R Frankenburg, MD; Chief Editor: Glen L Xiong, MD  more...
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The GRM3 gene is a protein-coding gene associated with bipolar affective disorder. In a 2014 study, researchers found a variant in the GRM3 gene that was associated with a two- to three-fold increase in the risk of developing schizophrenia or alcohol dependence and an approximately three-fold greater risk of developing bipolar disorder. In the study, researchers performed a genetic analysis of 4971 patients with schizophrenia, bipolar disorder, or alcoholism and of 1309 healthy controls. The GRM3 variant associated with schizophrenia, alcohol dependence, and bipolar disorder in the study, which is seen in about 1 of every 200 people, may be a nonspecific risk factor for mental disorders and a potential treatment target. [17, 22]

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